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KMID : 0613820070170060847
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Journal of Life Science
2007 Volume.17 No. 6 p.847 ~ p.858
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Endoplasmic Reticulum Signaling for Recombinant-protein Production
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Goo Tae-Won
Yun Eun-Young
Kang Seok-Woo
Kwon Ki-Sang
Kwon O-Yu
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Abstract
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The endoplasmic reticulum (ER) is an important intracellular organelle for folding and maturation of newly synthesized transmembrane and secretory proteins. The ER provides stringent quality control systems to ensure that only correctly folded proteins exit the ER and unfolded or misfolded proteins are retained and ultimately degraded. The ER has evolved stress response both signaling pathways the unfolded protein response (UPR) to cope with the accumulation of unfolded or misfolded proteins and ER overload response (EOR). Accumulating evidence suggests that, in addition to responsibility for protein processing, ER is also an important signaling compartment and a sensor of cellular stress. In this respect, production of biofunctional recombinant-proteins requires efficient functioning of the ER secretory pathway in host cells. This review briefly summarizes our understanding of the ER signaling developed in the recent years to help of the secretion capacities of recombinant cells.
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KEYWORD
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Endoplasmic reticulum (ER) stress, recombinant-protein, unfolded protein response (UPR), ER overload response (EOR), chaperone, ER quality control (ERQC), glycosylation
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